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The most common side effects may include flushing, feelings of tingling or heat, tiredness, weakness, drowsiness, or dizziness NDA 20-080/S-036 Package Insert Page 1 of 24 1 1 PRESCRIBING INFORMATION 2 IMITREX® 3 (sumatriptan succinate) 4 Injection 5 6 For Subcutaneous Use Only. For the treatment of migraine, if side effects are dose limiting, the lower dose of 4 mg may be used [see Clinical Studies ( 14. For treating migraine, Imitrex nasal spray may be prescribed in doses of 5 mg, 10 mg, or 20 mg. It’s FDA-approved to treat migraine with or without aura. 7 DESCRIPTION 8 IMITREX (sumatriptan succinate) Injection is a selective 5-hydroxytryptamine1 receptor. Typically, your doctor will prescribe a low or moderate starting dose of Imitrex. 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