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If your headache comes back or you only get some relief from your headache, you can take a second tablet 2 hours after the first tablet This medication is FDA-approved to treat migraine with or without aura in adults. They should be swallowed whole with water. Children under 18 This medicine is not recommended for children under 18 years old. You should not crush, cut, or chew Imitrex tablets. The safety of treating an average of more than 4 headaches in a 30 day period has not been established How much to take Adults aged 18 to 65 The usual dose for adults aged 18 to 65 is one 50mg tablet, swallowed whole with water. Imitrex basics Imitrex comes in three forms: a solution that you inject under your skin a tablet that you swallow a nasal spray The active drug in Imitrex is sumatriptan. Injection under the skin (subcutaneously or SC) Sumatriptan We will show you how to give a subcutaneous injection. If your migraine doesn’t go away, you can take an additional amount after a 2-hour gap. 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Migraine is a neurological* condition that causes severe, long-lasting headaches. It works by narrowing swollen blood vessels in your brain, which helps relieve the pain of migraine and cluster headaches. If your headache comes back or you only get some relief from your headache, you can take a second tablet 2 hours after the first tablet After you take the other medicine, check with your doctor right away. You can also read our information sheet to remind you. Each tablet contains 70 mg of sumatriptan succinate equivalent to 50 mg of sumatriptan Do not take more than 200 mg in 24 hours. Use after Imitrex Injection If the migraine returns following an initial treatment with Imitrex (sumatriptan) injection, additional single Imitrex tablets (up to 100 mg/day) may be given with an interval of at least 2 hours between tablet doses. 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